Hydrochlorothiazide is a drug with low aqueous solubility, used as a diuretic and also used in the management of mild to moderate hypertension. The major problem in oral administration of hydrochlorothiazide is its poor oral bioavailability. So in this investigation, liquisolid compacts were prepared with propylene glycol in different ratios of vehicle to increase the dissolution rate and subsequent increase in oral bioavailability. The drug and propylene glycol were taken in 1:2, 1:4 ratios with MCC and lactose as diluents. The prepared liquisolid granules were compressed into tablets and with 5 mm punch at 4kg/cm2 hardness. Hardness, drug content, weight variation, disintegration and dissolution tests were conducted. Similar compositions (without solvent vehicle) were made into tablets by wet granulation method and the dissolution rates were compared with liquisolid tablets. From the results it is found that the liquisolid technique was found to be more effective for drug release than conventional wet granulation technique. The effects of MCC and lactose on dissolution are statistically non significant (p<0.05). Among the liquisolid compacts 1:4 drug: propylene glycol ratio with micro crystalline cellulose was determined to be the best formulation with effective dissolution efficiency.
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